PURITY 99.99% API
FDA CGMP
NITROSAMINE <26.5 nanograms/day
5x THROUGHPUTS
20x LESS SOLVENT USED
ICH M7(R2)
Advanced Purification Technology

Optimized Pharmaceutical Process Technology

Our proprietary separation technology enables superior purification of active pharmaceutical ingredients and intermediates, eliminating contaminants and impurities while maintaining yields across commercial scales.

5x
Process Rates
99.99%
Purity Achieved
10-15x
Lower Cost of Operation
95%
Less Organic Solvent Usage

Nitrosamine Elimination

The definitive solution to the pharmaceutical industry's most critical contamination challenge.

Nitrosamine Structure
N-Nitrosamine
Genotoxic Impurity • Probable Carcinogen
NDMA
NDEA
NMBA
NIPEA
NDIPA
NDBA

From Crisis to Control

// The Challenge

Nitrosamines have triggered billions of dollars in recalls and shaken regulatory confidence worldwide. Conventional removal methods are either ineffective or are slow, destructive, and economically unsustainable at production scale.

// The Kirality Advantage

Our patent pending technology achieves selective removal of nitrosamines to concentrations beneath the newly established FDA acceptable intake (AI) limits, while minimizing valuable API losses—faster and at a fraction of conventional costs.

// A Versatile Design

This platform is effective on small molecule nitrosamines, as well as nitrosamine drug substance-related impurities (NDSRIs), ensuring comprehensive coverage of both problem classes.

<26.5
nanograms/day
FDA's acceptable intake threshold for nitrosamine impurities in a daily dose

Advanced Contamination Removal

Our cutting‑edge purification techniques drive impurities and contaminants far below regulatory thresholds, ensuring every API complies with the most stringent global standards.

Nitrosamine Detection Chromatogram
Eliminate genotoxic and mutagenic impurities – including nitrosamines and other hazardous species
Purge reaction intermediates of by‑product traces and catalyst residues
Remediate heavy metals, pesticides, herbicides, insecticides, miticides, and other environmental pollutants

From Assessment to Production

A streamlined pathway engineered for speed and precision.

01

Assessment

Comprehensive impurity profiling and process analysis

02

Optimization

Custom protocol development for your specific API

03

Purification

Precision separation achieving target specifications

04

Validation

Complete documentation for regulatory compliance

Capabilities

Our advanced purification technology serves diverse pharmaceutical manufacturing needs, from complex biologics to difficult isomer separations.

🧬

Biologics

Isolation of peptides, proteins, enzymes, and other biological compounds while preserving structural integrity and bioactivity.

💊

Pharmaceutical Excipients

Removal of impurities from excipients to meet stringent pharmaceutical grade specifications and regulatory requirements.

⚗️

Compound Separation

Selective separation of compounds, especially isomers, enabling chirally pure products and enhanced therapeutic efficacy.

Operator at Reactor

Initiate Contact

Reach out to our team to discuss your purification requirements. Our experts are ready to assess your specific challenges and develop customized solutions.

// Headquarters

Dallas, TX

Corporate Office

// Laboratories

Los Angeles, CA

R&D Center

info@kiralitypharma.com

Our team typically responds within one business day.